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SCH900776 S-isomer

CAS No. 891494-64-7

SCH900776 S-isomer( MK-8776 S-isomer )

Catalog No. M17644 CAS No. 891494-64-7

SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCH900776 S-isomer
  • Note
    Research use only, not for human use.
  • Brief Description
    SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).
  • Description
    SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 160 nM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MK-8776 S-isomer
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CDK2| Chk1| Chk2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    891494-64-7
  • Formula Weight
    376.25
  • Molecular Formula
    C15H18BrN7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL; 265.78 mM
  • SMILES
    Cn1cc(cn1)c1c2nc(c(c(n2nc1)N)Br)[C@H]1CCCNC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guzi TJ, et al. Mol Y Ther, 2011, 10(4), 591-602.
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